Extraskeletal cutaneous chondroblastic osteosarcoma: a case report.

Extraskeletal osteosarcoma is an uncommon neoplasm that usually arises in the deep soft tissues, especially in the lower extremities, with rare cases involving the subcutis or dermis. We report a 60-year-old man with an enlarging cutaneous mass in the right lower thigh. An incisional skin biopsy showed a well-defined, but non-encapsulated neoplasm, characterized by extensive cartilage with marked cellularity, atypia and high mitotic activity, involving the dermis and subcutis. Although osteoid or bone was not observed, a diagnosis of cutaneous chondroblastic osteosarcoma was suggested after excluding an origin in bone or other primary tumor sites by imaging techniques. Histopathologic features of the surgical specimen were characteristic, with a predominant high-grade chondroid component together with focal fibrosarcomatous zones, areas of multinucleated giant cells and foci of bone and osteoid formation. The patient underwent postoperative chemotherapy and is currently alive with pulmonary metastases 15 months after surgery. In summary, we report a unique case of cutaneous osteosarcoma of the chondroblastic subtype, diagnosed on incisional skin biopsy despite the absence of osteoid or bone during tumor sampling. As a rule, when an obviously malignant 'chondrosarcoma' is identified, one should always consider this entity.

Undifferentiated carcinoma of the jejunum with extensive rhabdoid features. Case report and review of the literature.

Malignant rhabdoid tumor, first described in the kidney of young infants, is a rare and highly aggressive neoplasm of controversial histogenesis that has been reported at many other sites, including the gastrointestinal tract. However, malignant rhabdoid tumor of the small intestine is very rare, with only seven cases published to date. We report a 70-year-old man who presented with abdominal pain and weight loss, and showed a perforated jejunal mass with disseminated metastases by imaging. The patient underwent partial jejunectomy and biopsy of a liver metastasis. Microscopically, the tumor was characterized by neoplastic cells with vesicular nuclei, large nucleoli and abundant eccentric cytoplasm with hyaline globular intracytoplasmic inclusions. Immunohistochemically, the neoplasm coexpressed vimentin and epithelial antigens (AE1/AE3, Cam 5.2, CK34betaE12, CK19 and EMA), most of them showing a peculiar immunostaining pattern in relation to the globular inclusions. Ultrastructurally, the inclusions corresponded to paranuclear whorls of intermediate filaments. The patient received postoperative chemotherapy but died 9 months after surgery. In summary, we report the exceptional case of an undifferentiated carcinoma of the jejunum with rhabdoid phenotype. As with tumors at other sites, recognition of rhabdoid morphology in small intestine neoplasms is of significance because the prognosis is extremely poor.

Miointimoma del glande del pene. A propósito de un caso y revisión de la literatura / Myointimoma of the glans penis. Report of a case and review of the literature

El término «miointimoma» fue usado por primera vez en el año 2000 para describir una proliferación miointimal característica que afecta al cuerpo esponjoso del glande del pene. Presentamos un caso de esta lesión mesenquimal infrecuente en un paciente de 68 años con un nódulo en el glande peneano. Los hallazgos histológicos revelaron una lesión mesenquimal sin relación con el epitelio que afectaba a los cuerpos esponjosos. Esta lesión consistía en una proliferación de células fusiformes sin atipia citológica, con arquitectura plexiforme y de localización intravascular. Revisamos la literatura y comentamos los diferentes diagnósticos diferenciales

The term «myointimoma» was first used in 2000 to describe a distinctive myointimal proliferation involving the corpus spongiosum of the glans penis. We present a case of this unusual mesenchymal lesion in a 68-yr-old male with a nodule located in the glans penis. The histological findings revealed a mesenchymal lesion not related to epithelium involving the corpus spongiosum. The process consists of non-atypical intravascular proliferation of spindle cells, with plexiform architecture. We review the literature and discuss the differential diagnostic possibilities

Miointimoma del glande del pene. A propósito de un caso y revisión de la literatura / Myointimoma of the glans penis. Report of a case and review of the literature

El término «miointimoma» fue usado por primera vez en el año 2000 para describir una proliferación miointimal característica que afecta al cuerpo esponjoso del glande del pene. Presentamos un caso de esta lesión mesenquimal infrecuente en un paciente de 68 años con un nódulo en el glande peneano. Los hallazgos histológicos revelaron una lesión mesenquimal sin relación con el epitelio que afectaba a los cuerpos esponjosos. Esta lesión consistía en una proliferación de células fusiformes sin atipia citológica, con arquitectura plexiforme y de localización intravascular. Revisamos la literatura y comentamos los diferentes diagnósticos diferenciales

The term «myointimoma» was first used in 2000 to describe a distinctive myointimal proliferation involving the corpus spongiosum of the glans penis. We present a case of this unusual mesenchymal lesion in a 68-yr-old male with a nodule located in the glans penis. The histological findings revealed a mesenchymal lesion not related to epithelium involving the corpus spongiosum. The process consists of non-atypical intravascular proliferation of spindle cells, with plexiform architecture. We review the literature and discuss the differential diagnostic possibilities

Metastasis of cutaneous malignant melanoma to angiolipoma: the tumor-to-tumor metastasis phenomenon.

BACKGROUND: Although the phenomenon of tumor-to tumor metastasis is not rare, it has been reported in only eight cases with malignant melanoma as the primary tumor. METHODS: This case describes a patient with cutaneous malignant melanoma that metastasized to an angiolipoma. To our knowledge this is the second case of a malignant melanoma metastasizing to another primary cutaneous tumor and the first to do so in a lipoma. CONCLUSION: In this report we present the clinical and histopathologic features of this special case and review the relevant literature.